How to take the two injections of Cronavirus most effectively?How long does it take to develop antibodies?How about the protection period?-- Yang Xiaoming, chairman of Sinopharm China Biology Group, explained the focus of vaccination

  Since December 15 last year, China has officially carried out the inoculation of coronavirus vaccine in key population.Have there been any serious adverse reactions in the newly vaccinated population in the past month?What is the most effective interval between two injections?How many days it takes to produce antibody?How about the protection period?Is there a difference in the effect of vaccination at different ages?...Xinhua interviewed Yang Xiaoming, chairman of Sinopharm China Biotech Co., Ltd., in an exclusive interview with the public about the highly publicized vaccine question.

Q: At the end of December, China national medicine group biological published by Beijing Ⅲ consideration phase of clinical trial data, the results show that immune program after two doses, turn neutralizing antibody positive rate was 99.52%, the vaccine protective efficacy of 79.34%.How to understand the validity of the two data statements?

A: Neutralizing antibodies can be commonly understood as antibodies that can fight pathogens and are the basis of vaccine protection.The 99.52% neutralizing antibody positive conversion rate means that 99.52% of subjects who received two doses of the vaccine developed neutralizing antibodies.However, the production of neutralizing antibodies does not mean that the vaccine is protective. An effective concentration of antibodies is required.Depending on individual differences, the same concentration of antibodies may have different protective effects on different people.The protective efficacy was 79.34%, meaning that 79.34% of the subjects were protected by the vaccine.

  There are differences in case diagnosis criteria and procedures among countries.86% of the protection effectiveness data approved by the UAE and 79.34% of the protection effectiveness data approved by the Chinese drug regulatory authority are true and effective.The analysis data of UAE and China are also consistent. For example, the positive conversion rate of neutralizing antibody is more than 99%, and the protection rate for moderate and severe patients is 100%.At present, the safety and effectiveness indicators exceed the marketing standards set by the World Health Organization and the requirements of the conditional marketing work program approved by our country, which can form effective protection in a large range of people.

Q: Sinopharmaceutical China biological  Coronavirus inactivated vaccine number of the latest inoculation?Have any new symptoms of serious adverse reactions been detected?

A: Since our country officially started the emergency use of coronavirus vaccine on July 22 last year, as of January 4, 2021, domestic emergency use has been inoculated the Chinese biological  coronavirus inactivated vaccine of state medicine group more than 4 million times.Since the campaign began on December 15 last year, efforts have been made to increase the number of vaccinations, with more than 10 million doses being administered nationwide.

During the first month of the vaccination in the key population, the adverse reactions we detected were mainly local reactions, mainly pain at the vaccination site, and systemic reactions mainly included headache, myalgia and fever, which were far lower than the side effects of the common vaccine already on the market.

Q: The Coronavirus vaccine vaccination regimen in China uses two injections with optional intervals of two, three or four weeks. What are the differences in the effects of different programs?How to choose?

A: In the clinical trial of l Coronavirus vaccine, we have explored different vaccination regiments with different doses, and the results show that the efficacy is best at three and four weeks intervals, and the duration of immunity, antibody positive conversion level, antibody mean value and other indicators are better than those at one and two weeks intervals.

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